Growing wild across Indonesia’s fields and gardens, Physalis angulata — locally known as ciplukan — has long been part of traditional remedies. Its small lantern-like husks hide sweet, tangy fruits, but its leaves and stems hold an even greater secret: potent medicinal compounds.

A Universitas Padjadjaran research team led by Dr. Hesti Lina Wiraswati tested ethanol extracts of ciplukan on laboratory fibroblast cells to evaluate antioxidant, anti-inflammatory, and anti-fibrotic activities. The experiments revealed that the extract not only neutralized harmful free radicals but also suppressed inflammatory markers and inhibited the migration of fibrosis-related cells.

Analytically, the suppression of HIF-1α and IL-6 — two key genes linked to tissue scarring — provides a biological explanation for the plant’s healing properties. This supports its potential in preventing or treating fibrotic diseases, where excessive scar tissue damages organs.

By translating a common plant into a scientifically validated therapeutic candidate, the study bridges traditional knowledge with modern medicine, offering a sustainable, locally sourced health solution aligned with SDG 3 and SDG 15: Life on Land.